Systematic anticancer therapy-induced peripheral & central neurotoxicity: ESMO-EONS-EANO Clinical Practice Guidelines

Ann Oncol. 2020 Oct; 31(10):1306-1319. Epub 2020 Jul 30.
Type:
Practice Guidelines
PMID:
32739407
DOI:
10.1016/j/annonc.2020.07.003
Authors:

B Jordan1, A Margulies2, F Cardoso3, G Cavaletti4, H S Haugnes5, P Jahn6, E Le Rhun7, M Preusser8, F Scotté9, M J B Taphoorn10, K Jordan11, on behalf of the ESMO Guidelines Committee, the EONS Education Working Group and the EANO Guideline Committee

Author Affiliations:

1Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany.
2European Oncology Nursing Society, Brussels, Belgium.
3Breast Unit, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.
4Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
5Department of Oncology, University Hospital of North Norway, Tromsoe, Norway; Institute of Medicine, UIT - The Arctic University, Tromsoe, Norway.
6University of Halle, Nursing Research Unit, Halle, Germany.
7University of Lille, Inserm, U-1192, Lille, France; CHU Lille, Neuro-oncology, General and Stereotaxic Neurosurgery Service, Lille, France; Breast Cancer Department, Oscar Lambret Center, Lille cedex, France; Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
8Clinical Division of Oncology, Comprehensive Cancer Center CNS Tumours Unit, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
9Gustave Roussy Cancer Campus, Interdisciplinary Cancer Course Department, Villejuif, France.
10Department of Neurology, Leiden University Medical Center and Department of Neurology, Haaglanden Medical Center, The Hague, The Netherlands.
11Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany

Abstract
Purpose

• This ESMO–EONS–EANO Clinical Practice Guideline provides key recommendations on the management of therapy-induced peripheral and central neurotoxicity
• Authorship includes a multidisciplinary group of experts from different institutions and countries in Europe and abroad
• Recommendations are based on available scientific data and the authors’ collective expert opinion
• An algorithm on the practical approach to assessing chemotherapy-induced peripheral neurotoxicity is provided

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