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  • Welcome to the Scalp Cooling Study Library 

    The Scalp Cooling Study Library unites key clinical research studies and data to provide an independent overview of global research and practice on scalp cooling and cryotherapy for chemotherapy side effect management.
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  • The Scalp Cooling Registry

    Learn more about largest real-world study of 7,424 patients that aimed to ascertain the determinants for scalp cooling efficacy.
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The Paxman Clinical Efficacy Brochure combines robust evidence from across the world into four key areas: Efficacy & Retention, Hair Regrowth & Preventing PCIA, Improving Quality of Life, and Safety & Tolerability.
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Take a deeper dive below into some of the studies featured by downloading the full papers.

Effect of scalp cooling on alopecia in women undergoing chemotherapy for breast cancer. The SCALP trial

A multicentre, randomised, non-blinded study on women undergoing chemotherapy for Stage I or II breast cancer treatment in the adjuvant or neo-adjuvant setting. Patients were randomly assigned scalp cooling or no scalp cooling on a 2:1 ratio. Type of chemotherapy:…

Efficacy of scalp cooling in preventing and recovering from chemotherapy-induced alopecia in Breast Cancer Patients: the HOPE study

This multicentre, controlled trial in 5 clinical sites in Japan aimed to assess the efficacy of the Paxman scalp cooling (SC) system in preventing chemotherapy-induced alopecia in Japanese breast cancer patients, and to also investigate whether the device improved hair…

Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia

An open label randomised single centre study with 51 female Indian breast cancer patients was used to evaluate the effect of the Paxman scalp cooling device on preventing CIA among women undergoing (neo) adjuvant chemotherapy (CT) containing both anthracyclines and…

Scalp cooling with adjuvant/neoadjuvant chemotherapy for breast cancer & the risk of scalp metastases

A systematic review and meta-analysis evaluated the risk of scalp metastases in breast cancer chemotherapy patients undergoing and not undergoing scalp cooling. Several electronic databases were searched for information relating to chemotherapy, breast cancer and scalp metastases. Timing of chemotherapy:…

Scalp cooling for hair preservation & associated characteristics in 1411 chemotherapy patients - Dutch Scalp Cooling Registry

The Dutch Scalp Cooling Registry collected data from 28 Dutch hospitals. Questionnaires were completed by nurses and patients to examine the success of scalp cooling and any side effects. Method of scalp cooling: Paxman Scalp Cooler (PSC-1 or PSC-2)

Prospective study of hair recovery after (neo)adjuvant chemotherapy with scalp cooling in Japanese breast cancer patients

Scalp cooling during chemotherapy infusion to mitigate alopecia for breast cancer patients is becoming widespread; however, studies regarding hair recovery after chemotherapy with scalp cooling are limited. We conducted a prospective study of hair recovery after chemotherapy with scalp cooling.

Scalp Cooling in Preventing Persistent Chemotherapy-Induced Alopecia: A Randomized Controlled Trial

Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer

Chemotherapy-induced alopecia is a common and distressing adverse effect. In previous studies of scalp cooling to prevent chemotherapy-induced alopecia, conclusions have been limited.

Abstract P5-08-10: Safety and Tolerability of Paxman Scalp Cooling at Lower Temperatures to Improve Efficacy with Anthracycline Chemotherapy

Chemotherapy induced alopecia is one of the most distressing side effects of cancer therapy since it is a constant reminder of the underlying malignancy. Anthracycline chemotherapy induces total alopecia. Although scalp cooling devices have been used to prevent this alopecia,…